What does ADAM17 stand for?
By Caleb Butler
What does ADAM17 stand for?
View/Edit Mouse. A disintegrin and metalloprotease 17 (ADAM17), also called TACE (tumor necrosis factor-α-converting enzyme), is a 70-kDa enzyme that belongs to the ADAM protein family of disintegrins and metalloproteases.
What activates ADAM17?
Recent studies established a new model of ADAM17 activation. Activators of ADAM17 induce phosphatidylserine exposure at the outer leaflet of the cell membrane, which causes ADAM17 to bind to the membrane via its MPD and CANDIS and thereby facilitates the shedding process19,20.
How does ADAM17 work?
ADAM17 activities include shedding of receptors, cytokines and growth factors leading to subsequent ripping of transmembrane proteins by the intramembrane protease γ-secretase, which cleaves single-pass transmembrane proteins within the transmembrane domain.
Where is ADAM17 found?
ADAM-17 (synonyms: CD156b; cSVP; MGC71942; TACE) was described as a protein of 824 amino acids (accession number NM_003183), and its gene is located on chromosome 2p25.
What is the function of a Disintegrin?
Disintegrins are a family of small proteins (45–84 amino acids in length) from viper venoms that function as potent inhibitors of both platelet aggregation and integrin-dependent cell adhesion.
What is a protein Ectodomain?
An ectodomain is the domain of a membrane protein that extends into the extracellular space (the space outside a cell). Ectodomains are usually the parts of proteins that initiate contact with surfaces, which leads to signal transduction.
What is Sheddase enzyme?
Sheddases are membrane-bound enzymes that cleave extracellular portions of transmembrane proteins, releasing the soluble ectodomains from the cell surface. Many sheddases are members of the ADAM or aspartic protease (BACE) protein families.
What is Disintegrin domain?
Description. Disintegrins are a family of small proteins from viper venoms that function as potent inhibitors of both platelet aggregation and integrin-dependent cell adhesion. [1, 2] .
What is Echistatin?
Echistatin is a single-chain polypeptide with a molecular weight of 5400 and a native isoelectric point of 8.3. The most abundant amino acid, cysteine, accounts for 8 of the 49 residues in the protein.
What is Ectodomain of virus?
Ectodomains are usually the parts of proteins that initiate contact with surfaces, which leads to signal transduction. A notable example of an ectodomain is the S protein, commonly known as the spike protein, of the viral particle responsible for the COVID-19 pandemic.
What is extracellular receptor?
Extracellular signaling receptors are classified into two main groups according to their location in the cell: cell surface receptors, located in the plasma membrane, and nuclear transcription factor receptors located inside the cell.
Is Ectodomain the same as extracellular domain?
